課程名稱 |
去氧核糖核酸損傷、修復、和癌症 DNA Damage, Repair, and Cancer |
開課學期 |
108-2 |
授課對象 |
生命科學院 生化科學研究所 |
授課教師 |
冀宏源 |
課號 |
BChem5047 |
課程識別碼 |
B46 U1070 |
班次 |
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學分 |
2.0 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期一6,7(13:20~15:10) |
上課地點 |
生化N101 |
備註 |
與李弘文、詹迺立、林敬哲、吳青錫、張智芬合授 總人數上限:50人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1082BChem5047_ |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
In this course, we will discuss the sources of DNA damage and how cells sense and respond to DNA lesions. Multiple DNA repair pathways, their discovery histories and new technologies for measuring DNA damages and repair will be covered in the lectures. Our genome integrity is maintained by a multitude of DNA repair and DNA damage response mechanisms. The failure of these mechanisms can result in a variety of diseases including cancer. The application of DNA damage and repair in therapeutic intervention in cancer and genome editing will be also introduced. |
課程目標 |
Through this course, students will be familiar with the fundamental knowledge of DNA damage, repair, and cancer. In addition, students will learn the classical and advanced methodology to study DNA damage and repair. We will also motivate students to ask questions and engage them to participate in the discussion. |
課程要求 |
We encourage students to take Biochemistry course before attending this class. |
預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
待補 |
參考書目 |
1. Genome Stability, James E. Haber, 2014
2. Advanced review articles from each session |
評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
3/02 |
I. DNA Damages and Repair systems
DNA damage sources and mutations
|
第2週 |
3/09 |
DNA repair systems |
第3週 |
3/16 |
DNA break repair |
第4週 |
3/23 |
Crosstalk between repair pathways |
第5週 |
3/30 |
Session I discussion |
第6週 |
4/06 |
溫書假 |
第7週 |
4/13 |
II. Biophysical, Imaging and Structural Approaches to study DNA repair mechanisms
Tools to study protein-DNA binding
|
第8週 |
4/20 |
Single-molecule imaging tools |
第9週 |
4/27 |
Structural basis of nucleic acids processing |
第10週 |
5/04 |
Structural basis of DNA repair machineries |
第11週 |
5/11 |
Session II discussion |
第12週 |
5/18 |
III. DNA Repair and Cancer
Sensing DNA damage and the signal response
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第13週 |
5/25 |
DNA damage response and cancer |
第14週 |
6/01 |
Genome instability of cancer |
第15週 |
6/08 |
DNA damage and repair in cancer therapy |
第16週 |
6/15 |
Session III discussion |
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